3. Cooldown Reduction and Resource Management Synergy
To efficiently manage both resource regeneration and cooldowns, consider these two synergies:

Cooldown Reduction (CDR) and Resource Pool Management
Some abilities or items in Diablo 4 can reduce the time needed to use a cooldown ability again (CDR). By stacking CDR effects, you can significantly reduce the time between high-impact abilities like Ultimate skills, defensive cooldowns, and crowd control abilities. When combined with a fast resource generation strategy, you’ll be able to keep up the pressure on Vilnuus and mitigate damage more consistently.

Cooldown Reduction Items: Look for items, gems, or passive effects that reduce cooldown times, enabling you to use your most powerful abilities more often.
Resource Cost Reduction: Some effects reduce the resource cost of your most powerful abilities. This lets you spam these abilities even more often while not draining your resource pool too quickly.
Smart Resource Usage
If you have resource regeneration abilities that don’t consume a lot of resources, you can use them in between big cooldowns to quickly fill up your pool for the next offensive or defensive ability. This helps you make the most of your cooldowns without worrying about running out of resources in the middle of a big attack.

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